Almost every probiotic on the shelf is sold on a top-up model. Your gut is a jar, good bacteria have gone missing from it, and a supplement refills the jar. It is an easy story to tell. It is also not how a microbiome behaves.
The bacteria in your large intestine compete for space and food, signal to each other chemically, crowd each other out and respond within hours to what you eat and how you sleep. Pouring a few billion cells of one species into a system with trillions of residents is not a refill. At best it is an input into an ongoing conversation.
Bio-regulation is our name for designing around that reality: support the conditions, feed the residents, deliver the cultures in a form that survives the trip, and be specific about what is known and what is not.